| 疏水缔合水溶性聚合物P(DMDAAC-NVP-IOA)与萘普生相互作用及释药性 |
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| 引用本文： | 王新龙,张跃军.疏水缔合水溶性聚合物P(DMDAAC-NVP-IOA)与萘普生相互作用及释药性[J].应用化学,2008,25(12):1393-0. |
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| 作者姓名： | 王新龙 张跃军 |
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| 作者单位： | 南京理工大学 |
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| 基金项目： | 国家科技攻关项目
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| 摘 要： | 以水为介质,采用自由基胶束聚合制备了二甲基二烯丙基氯化铵(DMDAAC)、N-乙烯基吡咯烷酮(NVP)和丙烯酸异辛酯(IOA)三元共聚疏水缔合水溶性聚合物P(DMDAAC-NVP-IOA),测定了聚合物的聚电解质性质和疏水缔合性质.应用IR、XRD、DSC测试技术研究了各组分的相互作用.结果表明,所制备的P(DMDAAC-NVP-IOA)同时具有聚电解质和疏水缔合特性.随P(DMDAAC-NVP-IOA)量增加,IR分析中萘普生羧基的羰基伸缩振动峰1 684 cm-1处峰变宽、强度明显减弱;XRD分析中的12°～29°间衍射峰逐渐变宽、变小直至消失;DSC分析中只有1个转变曲线,P(DMDAAC-NVP-IOA)与萘普生之间存在分子级相互作用.在pH=7.4磷酸盐缓冲液中,疏水缔合水溶性聚合物具有药物缓释特性,可用扩散-溶解模型进行最佳拟合.
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| 关 键 词： | 疏水缔合 水溶性聚合物 萘普生 缓释 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2009-06-29 |
Interactions of Hydrophobically Associating Poly(DMDAAC-NVP-IOA) with Naproxen and Its Drug Release Characteristics |
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| WANG Xin-Long,ZHANG Yue-Jun.Interactions of Hydrophobically Associating Poly(DMDAAC-NVP-IOA) with Naproxen and Its Drug Release Characteristics[J].Chinese Journal of Applied Chemistry,2008,25(12):1393-0. |
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| Authors: | WANG Xin-Long ZHANG Yue-Jun |
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| Institution: | WANG Xin-Long*,ZHANG Yue-Jun(College of Chemical Engineering,Nanjing University of Science , Technology,Nanjing 210094) |
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| Abstract: | Poly(DMDAAC-NVP-IOA) was prepared from dimethyldiallylammonium chloride(DMDAAC),N-vinyl pyrrolidone(NVP) and isooctyl acrylate(IOA) via radical micellar polymerization in water.The polyelectrolyte and hydrophobic association properties of the polymer were studied.The interactions of P(DMDAAC-NVP-IOA) with naproxen were investigated by IR,XRD and DSC.As the amount of P(DMDAAC-NVP-IOA) increased,the peak at 1 684 cm-1 assigned to the carbonyl of naproxen became broader and the peak intensity decreased.The dif... |
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| Keywords: | hydrophobically associating water-soluble polymer naproxen sustained-release |
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