Total synthesis of calystegine A7 |
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| Authors: | René Csuk,Erik Prell,Stefan Reiß mann |
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| Affiliation: | Bereich Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Strasse 2, D-06120 Halle (Saale), Germany |
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| Abstract: | A straightforward chiral pool synthesis for the glycosidase inhibitor calystegine A7 (isolated from Lycium chinense) from methyl α-d-glucopyranoside is described. Keysteps of this synthesis include a ultrasound assisted Zn-mediated tandem ring opening reaction followed by a Grubbs' catalyst mediated ring closure metathesis. |
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| Keywords: | Calystegine A7 Total synthesis Glycosidase inhibitor |
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