手性(硫)脲衍生物在不对称有机催化反应中的应用

手性(硫)脲衍生物是各种亲核试剂对亚胺、醛、缺电子烯烃加成反应的非常有效的有机催化剂之一, 已成功应用于对映选择性催化Strecker反应、Michael加成反应、Mannich反应、Baylis-Hillman反应、Henry反应等一系列重要的有机合成反应. 手性(硫)脲衍生物具有催化活性高、对映选择性和功能基相容性好、易于制备和修饰、适用范围广等优点, 成为近年来研究较多的不对称反应有机催化剂. 对手性(硫)脲衍生物在有机催化不对称合成中的应用研究进展进行了评述.

Application of Chiral (Thio)urea Derivatives in Asymmet-ricOrganocatalysis

Chiral (thio)urea derivatives are very effective organocatalysts for the nuclephilic addition reac-tions of imines, aldehydes, electron-deficient olefins, etc. They have been successfully applied in varieties of enantioselective organic reactions, such as asymmetric Strecker, Michael addition, Mannich, Baylis-Hillman, Acyl-Pictet-Spengler and Henry reactions as well as the dynamic kinetic resolution. Chiral (thio)urea deriva-tives are rapidly emerging as versatile, high catalytic active, low catalyst loading, excellent enantioselective, high functional group tolerant, ease of prepared/modified organocatalyst for the promotion of a wide range of synthetically useful asymmetric processes. The application of chiral (thio)urea derivatives in asymmetric organocatalysis is reviewed in this paper.