Low‐Magnetization Magnetic Microcapsules: A Synergistic Theranostic Platform for Remote Cancer Cells Therapy and Imaging |
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Authors: | Wei Zhang Lin Deng Guangchao Wang Xianrong Guo Qiujin Li Jianfei Zhang Niveen M Khashab |
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Institution: | 1. School of Textiles, Tianjin Polytechnic University, Tianjin 300387, China, Key Laboratory of Advanced Textile Composites (Tianjin Polytechnic University), Ministry of Education, , Tianjin, 300387 China;2. Physical Sciences and Engineering Division, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), , Thuwal, 23955‐6900 Kingdom of Saudi Arabia;3. Advanced Nanofabrication, Imaging and Characterization Core Facilities, King Abdullah University of Science and Technology (KAUST), , Thuwal, 23955‐6900 Kingdom of Saudi Arabia |
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Abstract: | Multifunctional magnetic microcapsules (MMCs) for the combined cancer cells hyperthermia and chemotherapy in addition to MR imaging are successfully developed. A classical layer‐by‐layer technique of oppositely charged polyelectrolytes (poly(allylamine hydrochloride) (PAH) and poly(4‐styrene sulfonate sodium) (PSS)) is used as it affords great controllability over the preparation together with enhanced loading of the chemotherapeutic drug (doxorubicin, DOX) in the microcapsules. Superparamagnetic iron oxide (SPIOs) nanoparticles are layered in the system to afford MMC1 (one SPIOs layer) and MMC2 (two SPIOs layers). Most interestingly, MMC1 and MMC2 show efficient hyperthermia cell death and controlled DOX release although their magnetic saturation value falls below 2.5 emu g?1, which is lower than the 7–22 emu g?1 reported to be the minimum value needed for biomedical applications. Moreover, MMCs are pH responsive where a pH 5.5 (often reported for cancer cells) combined with hyperthermia increases DOX release predictably. Both systems prove viable when used as T2 contrast agents for MR imaging in HeLa cells with high biocompatibility. Thus, MMCs hold a great promise to be used commercially as a theranostic platform as they are controllably prepared, reproducibly enhanced, and serve as drug delivery, hyperthermia, and MRI contrast agents at the same time. |
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Keywords: | superparamagnetic iron oxide (SPIO) microcapsule hyperthermia theranostics magnetic resonance imaging (MRI) chemotherapy cancer stem cells |
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