Titanocene(II)-promoted, one-pot, three-component coupling of thioacetals, alkynyl sulfones, and carbonyl compounds: highly stereoselective formation of tert-homopropargyl alcohols |
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| Authors: | Takeda Takeshi Ando Maiko Sugita Takenori Tsubouchi Akira |
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| Affiliation: | Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan. takeda-t@cc.tuat.ac.jp |
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| Abstract: | Titanocene alkylidene complexes, generated by desulfurizative titanation of thioacetals with Cp2Ti[P(OEt)3]2, reacted with alkynyl methyl sulfones to produce organotitanium species, which gave tert-homopropargyl alcohols with high diastereoselectivity on treatment with aromatic and alpha,beta-unsaturated ketones. |
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