| 新的醚链双生物碱尖叶唐松草阿原碱的结构测定 |
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| 引用本文： | 林翠梧,苏镜娱,曾陇梅,李红,彭文烈,徐安龙.新的醚链双生物碱尖叶唐松草阿原碱的结构测定[J].高等学校化学学报,2000,21(12):1820-1823. |
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| 作者姓名： | 林翠梧 苏镜娱 曾陇梅 李红 彭文烈 徐安龙 |
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| 作者单位： | 1. 广西大学化学化工学院, 南宁 530004;
2. 中山大学化学化工学院, 广州 510275;
3. 中山大学生命科学学院, 广州 510275 |
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| 基金项目： | 国家自然科学基金! (批准号 :2 993 2 0 3 0 )资助 |
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| 摘 要： | 从尖叶唐松草〔Thalictrumacutifolium(Hand.Mazz.)Boivin〕根分离得到一种新生物碱(尖叶唐松草阿原碱).通过IR,MS,1HNMR,13CNMR,2DNMR(包括1H-1HCOSY,13C-1HCOSY,NOESY和HMBC)测定了其化学结构,发现由阿朴菲和原小蘖碱通过醚链连接.对多种肿瘤细胞的生长有抑制作用,并有凋亡现象出现,而且对正常细胞的毒性较小
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| 关 键 词： | 尖叶唐松草 醚链双生物碱 阿朴菲 原小蘖碱 尖叶唐松草阿原碱(Ⅰ) |
| 收稿时间： | 1999-10-25 |
Structure Determination of a Novel Ether-linkaged Bisalkaloid Acutiaporberine |
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| LIN Cui-Wu,SU Jing-Yu,ZENG Long-Mei,LI Hong-PENG,Wen-Lie,XU An-Long.Structure Determination of a Novel Ether-linkaged Bisalkaloid Acutiaporberine[J].Chemical Research In Chinese Universities,2000,21(12):1820-1823. |
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| Authors: | LIN Cui-Wu SU Jing-Yu ZENG Long-Mei LI Hong-PENG Wen-Lie XU An-Long |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Guangxi Univer sity, Nanning 530004, China;
2. School of Chemistry and Chemical Engineering, Zhongshan University, Guang zhou 510275, China;
3. School of Life Science, Zhong shan University, Guangz hou 510275, China |
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| Abstract: | Anovel ether linkaged bisalkaloid, acutiaporberine(Ⅰ) , was isolated from the root of Thalictrum acutifolium (Hand.Mazz.) Boivin.Its structure was determined by IR, MS, 1H NMR, 13C NMR, and2D NMR( 1H1HCOSY, 13C1H COSY, NOESY, and HMBC).Ether linkaged bisalkaloids, such as aporphine benzylisoguinoline type and bisbenzylisoquinoline type, have been found.Herein a novel type bisalkaloid composed of an aporphine and a protobebertine is reported for the first time.Compound Ⅰ can inhibit the growth of tumor cells and apoptosis can be seen.However, compound Ⅰ shows only slight toxic effects on normal soma cell lines |
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| Keywords: | Thalictrum acutifolium (Hand Mazz ) Boivin Ether linkaged bisalkaloid Aporphine Protobebertine Acutiaporberine(Ⅰ) |
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