Mixed-ligand chromium(III)-oxalate-pirydinedicarboxylate complexes: potential biochromium sources: kinetic studies in NaOH solutions and effect on 3T3 fibroblasts proliferation |
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Authors: | Ewa Kita Hasan Marai Lisiak Michał Miłosz Jasiński Tomasz Drewa |
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Institution: | (1) Department of Chemistry, N. Copernicus University, 87-100 Toruń, Poland;(2) Department of Tissue Engineering, N. Copernicus University, 850-092 Bydgoszcz, Poland |
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Abstract: | Base hydrolysis of Cr(ox)2(pda)]3− (where pda is N,O-bonded 2,4- and 2,5- pyridinedicarboxylic acid dianion) causes successive ligand dissociation and leads
to formation of a mixture of oligomeric chromium(III) species, known as chromates(III). The main reaction path proceeds through
Cr(ox)(pda)(OH)2]3− and Cr(pda)(OH)4]3− complexes. The kinetics of the first oxalate dissociation was studied spectrophotometrically, within the lower energy d–d
band region, at 0.4–1.0 M NaOH. The character of spectroscopic changes was consistent with a consecutive reaction model, where
the chelate-ring opening and the one-end bonded oxalato liberation are the first and the second reaction stages. The pseudo-first
order rate constants (k
obs0 and k
obs1) were calculated using SPECFIT software for an A → B → C reaction pattern. Additionally, kinetics of base hydrolysis of Cr(ox)3]3− were studied. The calculated rate constants were independent of OH
−
]. Kinetic parameters for the chelate-ring opening and the first oxalate dissociation were determined. Effect of the Cr(ox)2(pda)]3− and Cr(2,4-pda)3]3− complexes on 3T3 fibroblasts proliferation was studied. The results manifested low cytotoxicity of these complexes, which
makes them promising candidates for dietary supplements. |
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Keywords: | |
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