| A Novel Reductive Cyclization of o-Nitrobenzamides and Ketones Promoted by Low-valent Titanium Reagent |
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| 作者姓名： | 史达清 荣良策 王菊仙 庄启亚 屠树江 |
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| 作者单位： | DepartmentofChemistry,XuzhouNormalUniversity,Xuzhou,Jiangsu221116,China |
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| 基金项目： | Project supported by the Natural Science Foundation of Education Committee of Jiangsu Province (No. 03KJB150136). |
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| 摘 要： | A short and facile synthesis of a series of 1,2-dihydroquiazolin-4(3H)-ones was accomplished in good yields via novel reductive cyclization of o-nitrobenzamides with ketones promoted by TiCI4/Zn system. The structure was established on the basis of elemental analysis, IR,^1H NMR and confirmed by a single-crystal X-ray diffraction analysis. This method has the advantages of easily accessible starting materials, convenient manipulation and moderate to high yields.
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| 关 键 词： | 还原反应 环化反应 o-硝基苯甲酰胺 喹唑啉-4（3H）-酮 低价钛试剂 |
A Novel Reductive Cyclization of o-Nitrobenzamides and Ketones Promoted by Low-valent Titanium Reagent |
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| SHI,Da-Qing,a,bRONG,Liang-CeaWANG,Ju-XianaZHUANG,Qi-Yaa,b TU,Shu-Jianga,b a.A Novel Reductive Cyclization of o-Nitrobenzamides and Ketones Promoted by Low-valent Titanium Reagent[J].Chinese Journal of Chemistry,2004,22(7):743-746. |
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| Authors: | SHI Da-Qing a bRONG Liang-CeaWANG Ju-XianaZHUANG Qi-Yaa b TU Shu-Jianga b a |
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| Institution: | SHI,Da-Qing*,a,bRONG,Liang-CeaWANG,Ju-XianaZHUANG,Qi-Yaa,b TU,Shu-Jianga,b a Department of Chemistry,Xuzhou Normal University,Xuzhou,Jiangsu 221116,China b The Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province,Xuzhou,Jiangsu 221116,China |
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| Abstract: | A short and facile synthesis of a series of 1,2-dihydroquiazolin-4(3H)-ones was accomplished in good yields via novel reductive cyclization of o-nitrobenzamides with ketones promoted by TiCl4/Zn system. The structure was established on the basis of elemental analysis, IR, 1H NMR and confirmed by a single-crystal X-ray diffraction analysis. This method has the advantages of easily accessible starting materials, convenient manipulation and moderate to high yields. |
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| Keywords: | quinazolin-4(3H)-one low-valent titanium o-nitrobenzamide |
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