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Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages |
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| Authors: | Carolina Muscoli Daniela Salvemini Donatella Paolino Michelangelo Iannone Ernesto Palma Antonio Cufari Domenicantonio Rotiroti Federico Carlo Perno Stefano Aquaro Vincenzo Mollace |
| Institution: | (1) Faculty of Pharmacy, University of Catanzaro "Magna Graecia", Roccelletta di Borgia, Catanzaro, Italy;(2) MetaPhore Pharmaceuticals. Inc., 1910 Innerbelt Business Center Drive, 63114 St Louis, MO, USA;(3) Department of Pharmaceutical Sciences, University of Catania, Italy;(4) IBAF Centre, CNR, Roccelletta di Borgia, Catanzaro, Italy;(5) Department of Experimental Medicine and Biochemical Sciences, University of Rome "Tor Vergata", Rome, Italy;(6) IRCCS "L. Spallanzani", Rome, Italy |
| Abstract: | BackgroundOxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occuring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants of HIV-infected human primary macrophages (M/M). |
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