Preparation of enamides via palladium-catalyzed amidation of enol tosylates |
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| Authors: | Klapars Artis Campos Kevin R Chen Cheng-Yi Volante Ralph P |
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| Institution: | Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. artis_klapars@merck.com |
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| Abstract: | reaction: see text] A Pd-catalyzed coupling of enol tosylates and amides has been developed. Ligand screening revealed dipf as the most general ligand for this transformation. A variety of enol tosylates were coupled to an array of enamides in 58-97% yield. |
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