| Synthesis and Characterization of α-Hexadecyl-DOTA and its Gd(III) Chelate |
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| 引用本文： | 冯志明,李峰,雷春华,陈蓉,李晓如.Synthesis and Characterization of α-Hexadecyl-DOTA and its Gd(III) Chelate[J].中国化学,2004(5). |
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| 作者姓名： | 冯志明 李峰 雷春华 陈蓉 李晓如 |
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| 作者单位： | College of Chemistry and Chemical Engineering，Hunan Normal University，Changsha，Hunan 410081，China，College of Chemistry and Chemical Engineering，Hunan Normal University，Changsha，Hunan 410081，China，College of Chemistry and Chemical Engineering，Hunan Normal University，Changsha，Hunan 410081，China，College of Chemistry and Chemical Engineering，Hunan Normal University，Changsha，Hunan 410081，China，College of Chemistry and Chemical Engineering，Centralsouth University，Changsha，Hunan，410083，China |
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| 基金项目： | Project supported by the Department of Science and Technology of Hunan Province (No. OOSSY 1013-51). |
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| 摘 要： | Introduction Recent interest in polyazamacrocyclic paramagnetic Gd(III) chelates largely results form their clinical appli-cation for magnetic resonance imaging (MRI) contrast agents. The ligand DOTA (1,4,7,10-tetraazacyclodo- decane-N,N',N',N'-tetraacetic acid) forms one of the most thermodynamically stable and kinetically inert complexes with the trivalent lanthanide cations of any known chelate. These properties make Gd-DOTA one of the most effective and the safest MRI contrast …
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