Highly stereoselective aldol reactions of titanium enolates from lactate-derived chiral ketones |
| |
| Authors: | Solsona Joan G Romea Pedro Urpí Fèlix Vilarrasa Jaume |
| |
| Affiliation: | Departament de Química Orgànica, Universitat de Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Catalonia, Spain. |
| |
| Abstract: | [reaction: see text] Highly stereoselective titanium-mediated aldol reactions based on lactate-derived ketones are reported. The stereochemical outcome of the process depends on the protecting group (PMB or Bn) and the Lewis acid (i-PrOTiCl(3) or TiCl(4)) used in the enolization step, the corresponding anti-syn or syn-syn aldols being prepared in high yields and with diastereomeric ratios up to 99:1. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
