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| 3-[N-(4-甲基苯基)氨基羰基]-5-[4-(4-甲酸基苯甲氧基)苯亚甲基]-2,4-噻唑烷二酮的合成 | |
| 引用本文： | 郑礼康,金明,张敬先,韩世清. 3-[N-(4-甲基苯基)氨基羰基]-5-[4-(4-甲酸基苯甲氧基)苯亚甲基]-2,4-噻唑烷二酮的合成[J]. 合成化学, 2011, 19(6): 782-784,787 |
| 作者姓名： | 郑礼康 金明 张敬先 韩世清 |
| 作者单位： | 南京工业大学生命与制药工程学院,江苏南京,210009 |
| 基金项目： | 国家自然科学基金资助项目(20942006,21072095) |
| 摘 要： | 以对甲苯胺和对甲基苯甲酸甲酯为起始原料,经NBS溴化、亲核取代、酸水解和Knoevenagel缩合等6步反应合成了抗细菌生物膜化合物—3-[N-(4-甲基苯基)氨基羰基]-5-[4-(4-甲酸基苯甲氧基)苯亚甲基]-2,4-噻唑烷二酮,总收率57.3％,其结构经1H NMR,ESI-MS和元素分析确证. |
| 关 键 词： | 细菌生物膜 噻唑烷二酮 Knoevenagel缩合 合成 |
Synthesis of 3-[N-(4-methylphenyl)aminooxo]5-[4-(4-formyloxybenzyloxyl)benzylidene]-2,4-thiazolanedine |
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| ZHENG Li-kang,JIN Ming,ZHANG Jing-xian,HAN Shi-qing. Synthesis of 3-[N-(4-methylphenyl)aminooxo]5-[4-(4-formyloxybenzyloxyl)benzylidene]-2,4-thiazolanedine[J]. Chinese Journal of Synthetic Chemistry, 2011, 19(6): 782-784,787 | |
| Authors: | ZHENG Li-kang JIN Ming ZHANG Jing-xian HAN Shi-qing |
| Affiliation: | ZHENG Li-kang,JIN Ming,ZHANG Jing-xian,HAN Shi-qing(College of Life Science and Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 210009,China) |
| Abstract: | A antibiofilm agent,3-[N-(4-methylphenyl)aminooxo]-5-[4-(4-formyloxybenzyloxyl)benzylidene]-2,4-thiazolanedine,was synthesized by six reaction of NBS bromization,nucleophilic substitution,acid hydrolysis and Knoevenagel condensation from 4-methylaniline and 4-(methoxycarbonyl)toluene.The overall yield was 57.3% and the structures were confirmed by 1H NMR,ESI-MS and elemental analysis. |
| Keywords: | bacterial biofilm thiazolidinedione Knoevenagel condensation synthesis |
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