| 基于质谱技术的代谢组学研究及其在中国的发展 |
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| 引用本文： | 王献,林树海,蔡宗苇.基于质谱技术的代谢组学研究及其在中国的发展[J].中国科学:化学,2014(5):76-77,726,731. |
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| 作者姓名： | 王献 林树海 蔡宗苇 |
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| 作者单位： | [1]中南民族大学化学与材料学院,武汉430074 [2]香港浸会大学环境与生物分析国家重点实验室,香港九龙 |
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| 基金项目： | 国家自然科学基金(21275167);香港研究资助局(HKBU5/CRF/10)资助 |
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| 摘 要： | 代谢组学是关于生物系统代谢物组成及变化规律的科学,是系统生物学的重要组成部分.质谱技术是目前代谢组学研究中最主要的分析手段之一,广泛应用于代谢组学各个领域.本文阐述了基于质谱技术的代谢组学方法及其应用,重点介绍和评论了近年来我国在该领域取得的进步和成果,并对基于质谱技术的代谢组学研究目前存在的问题及未来的发展进行了分析与展望.
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| 关 键 词： | 代谢组学 质谱技术 系统生物学 |
Mass spectrometry-based metabolomics and their developments in China |
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| WANG Xian,LIN ShuHai,CAI ZongWei.Mass spectrometry-based metabolomics and their developments in China[J].Scientia Sinica Chimica,2014(5):76-77,726,731. |
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| Authors: | WANG Xian LIN ShuHai CAI ZongWei |
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| Institution: | 1 College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, China 2 State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon, China) |
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| Abstract: | As an important component of systems biology, metabonomics （or metabolomics） is a science of studying metabolites and the corresponding changes in living systems. Mass spectrometry is one of the primary analytical tools of metabolomic studies and has been widely applied in many research areas. This paper overviews the recent developments in technologies and applications of mass spectrometry-based metabolomics, highlights major progress and achievement that have been recently gained in China in this field, and discusses the existing problems of mass spectrometry-based metabolomics and the future perspectives. |
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| Keywords: | metabonomics mass spectrometry systems biology |
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