| (+)-甘油醇缩丙酮合成工艺的研究 |
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| 引用本文： | 严子耳,罗一鸣,唐瑞仁.(+)-甘油醇缩丙酮合成工艺的研究[J].广州化学,2004,29(4):9-13. |
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| 作者姓名： | 严子耳 罗一鸣 唐瑞仁 |
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| 作者单位： | 中南大学,化学化工学院,湖南,长沙,410083;中南大学,化学化工学院,湖南,长沙,410083;中南大学,化学化工学院,湖南,长沙,410083 |
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| 摘 要： | 研究了以无水氯化锌为催化剂,D-甘露醇与丙酮缩合反应合成二异亚丙基缩合物的最适宜反应条件,产率可达65%。并通过NaIO4氧化断链,NaBH4还原得到(+)-甘油醇缩丙酮。分析了每步反应产物各组分的情况,发现副产物对目标产物的合成并无影响。
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| 关 键 词： | D-甘露醇 丙酮 (+)-甘油醇缩丙酮 合成 质谱 |
| 文章编号： | 1009-220X(2004)04-0009-05 |
| 修稿时间： | 2004年4月28日 |
The Synthesis of (+)-1,2-O-Isopropylideneglycerol |
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| YAN Zi-er,LUO Yi-ming,TANG Rui-ren.The Synthesis of (+)-1,2-O-Isopropylideneglycerol[J].Guangzhou Chemistry,2004,29(4):9-13. |
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| Authors: | YAN Zi-er LUO Yi-ming TANG Rui-ren |
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| Abstract: | The 1,2:5,6-di-O-methylethylidene-D-mannitol has been prepared from D-mannitol with anhydrous zinc chloride as the catalyst. The optimum synthetic condition has been studied in detail and the yield of the reaction is 65%. Firstly, the product was oxidized by NaIO4 and then deoxidized by NaBH4 to yield (+)-1,2-O-isopropylideneglycerol. Furthermore, the outgrowths were analyzed and it was found that the outgrowths had no influence on the synthesis of the target compound. |
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| Keywords: | D-mannitol acetone (+)-1 2-O-isopropylideneglycerol synthesis mass spectrum |
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