A novel synthetic route to 2-alkylpropane-1,3-sultones and its application to the synthesis of 2-alkyl derivatives of tramiprosate |
| |
| Authors: | Benoit Bachand Mohamed Atfani Bita Samim Sophie Lévesque Daniel Simard Xianqi Kong |
| |
| Institution: | Department of Chemistry, Neurochem Inc., 275, boul. Armand-Frappier, Laval, QC, Canada H7V 4A7 |
| |
| Abstract: | A practical synthetic route to various 2-alkylpropane-1,3-sultones, the key intermediates for the preparation of 2-substituted homotaurines as analogs of tramiprosate, was developed. |
| |
| Keywords: | Sultones Tramiprosate (3-amino-1-propanesulfonic acid) Alzheimer&rsquo s disease Amyloid β (Aβ) |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
