Novel ring B abeo-sterols as growth inhibitors of Mycobacterium tuberculosis isolated from a Caribbean Sea sponge, Svenzea zeai |
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| Authors: | Xiaomei Wei Yuehong Wang |
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| Affiliation: | a Department of Chemistry, University of Puerto Rico, PO Box 23346, U.P.R. Station, San Juan 00931-3346, PR, USA
b Institute for Tuberculosis Research, College of Pharmacy, The University of Illinois at Chicago, IL 60612-7231, USA |
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| Abstract: | Assay-guided fractionation of a moderately strong anti-tubercular extract obtained from the Caribbean Sea sponge Svenzea zeai afforded two novel 5(6 → 7)abeo-sterols, named parguesterols A (1) and B (2), as its active components. Their structures were elucidated on the basis of extensive spectroscopic analysis. |
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| Keywords: | Tuberculosis Caribbean sponge Mycobacterium tuberculosis Abeo-sterols Svenzea zeai |
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