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Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia |
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| Authors: | Cheng-Zhu Wu Xing Fu Cai Seong Su Hong Eun-Kyoung Seo Ji-Xing Nan Jung Joon Lee |
| Institution: | a Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea b Key Laboratory of Organism Functional Factors of the Changbai Mountain, Ministry of Education and College of Pharmacy, Yanbian University, Yanji 133002, China c Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea d College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea e College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea |
| Abstract: | Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC50 value of 6.1 μM. |
| Keywords: | Psoralea corylifolia Fabaceae Meroterpenoid Hypoxia-inducible factor-1 |
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