一种吲哚螺吡咯多取代杂环化合物的合成及其晶体结构

利用多组分1,3偶极环加成反应方法,合成了一种新的螺环结构1'-甲基-3'-吡啶甲酰基-4'-(2-噻吩基)螺吲哚啉-3,2'-吡咯啉]-2-酮化合物,并对该化合物进行了红外光谱、核磁共振谱及X-射线单晶衍射表征.单晶衍射结果表明:该晶体属于三斜晶系,空间群为P-1,晶体参数为a=0.899 9(1)nm,b=0.914 4(1)nm,c=1.271 1(2)nm,α=92.852(1)°,β=107.305(2)°,γ=101.580(1)°.在分子晶体结构中,吡咯啉环采用了信封式构象,通过螺碳原子与吲哚啉环相连,形成刚性螺环结构,2个环接近垂直构型,其二面角为84.15(2)°.

Synthesis and crystal structure of 1'-methyl-3'-picolinoyl-4'-(thiophen-2-yl) spiro[indoline-3,2'-pyrrolidin]-2-one

The new compound,1'-methyl-3'-picolinoyl-4'-(thiophen-2-yl) spiro indoline-3,2'-pyrrolidin]-2-one,was synthesized by one-pot three-component 1,3-dipolar cyclicaddition reaction and fully characterized by IR,1H NMR,13C NMR and single X-ray diffraction.The crystal of the title compound belongs to triclinic,space group P-1 with a=0.899 9(1) nm,b=0.914 4(1) nm,c=1.271 1 (2) nm,α=92.852 (1)°,β=107.305(2)°,y=101.580 (1)°.In the crystal structure,the pyrrolidin ring adopts envelope conformation,which links with the indole ring by the spiro-carbon atom.The two planes have almost vertical configuration with the dihedral angle of 84.15 (2)°.