Synthesis of Some Aminophosphonates Bearing N‐(Fluorophenyl)‐piperazynyl Moiety and Their Activity toward Serotonin Receptors |
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| Authors: | Andrzej Jó?wiak Pawe? Tokarz Piotr M Zagórski Ró?a Hamera Dariusz Cal Grzegorz Sata?a Andrzej J Bojarski |
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| Institution: | 1. Department of Organic Chemistry, Faculty of Chemistry, University of ?ód?, 91‐403 ?ód?, Poland;2. Department of Organic & Applied Chemistry, Faculty of Chemistry, University of ?ód?, 91‐403 ?ód?, Poland;3. Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, 31‐343 Kraków, Poland |
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| Abstract: | Syntheses of a series of compounds bearing a 1‐(fluorophenyl)piperazin‐4‐ylmethyl moiety, namely dialkyl 1‐(fluorophenyl)piperazin‐4‐ylmethyl phosphonates 3a–f , diethyl 2‐1‐(fluorophenyl)piperazin‐4‐yl]‐ethyl phosphonates 4a,b , diethyl 3‐1‐(4‐fluorophenyl)‐piperazin‐4‐yl]‐propyl phosphonate 5 , and di1‐(fluorophenyl)piperazin‐4‐yl]methanes 6a,b were performed, and some of them were screened for their affinity for serotonin 5‐HT1A, 5‐HT6, and 5‐HT7 receptors. Moderate interactions with these receptors were demonstrated. |
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