A new xanthone derivative from mangrove endophytic fungus No. ZSU-H16 |
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| Authors: | Zhongjing Huang Ruiyun Yang Zhiyong Guo Zhigang She Yongcheng Lin |
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| Institution: | (1) College of Chemistry and Ecology Engineering, Guangxi University for Nationalities, 530006 Nanning, P. R. China;(2) College of Chemistry and Chemical Engineering, Guangxi Normal University, 541004 Guilin, P. R. China;(3) College of Chemistry and Life Science, China Three Gorges University, 443002 Yichang, P. R. China;(4) College of Chemistry and Chemical Engineering, Sun Yat-Sen (Zhongshan) University, 510275 Guangzhou, P. R. China; |
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| Abstract: | A new xanthone derivative, 3,5,8-trihydroxy-2,2-dimethyl-3,4,4-trihydro-2H,6H-pyrano3,2-b]-xanthen-6one (1), together with three known compounds, 5,8-dihydroxy-2,2-dimethyl-2H,6H-pyrano3,2-b]xanthen6-one (2), cyclo-(N-O-methyl-L-Trp-L-Ile-D-Pip-L-2-amino-8-oxo-decanoyl) (3), and cyclo-(Phe-Tyr) (4), was isolated from the mangrove endophytic fungus No. ZSU-H16 obtained from the South China Sea coast. Their structures
were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. Compound 1 exhibited cytotoxicity against KB and KBV 200 cells with IC50 values greater than 50 μg/mL, respectively. |
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