4个天然1,7-二芳基庚烷类化合物的合成

合成了4个天然1,7-二芳基庚烷类化合物:1-(4′-羟基-3′-甲氧基苯基)-7-(4″-羟基苯基)-5-羟基-3-庚酮(1),1-(4′-羟基-3′-甲氧基苯基)-7-(4″-羟基苯基)-4-庚烯-3-酮(2),1-(3′,4′-二羟基苯基)-7-(4″-羟基苯基)-5-羟基-3-庚酮(3),1-(3′,4′-二羟基苯基)-7-(4″-羟基苯基)-4-庚烯-3-酮(4).化合物1,2,4为首次合成.

Studies on the Synthesis of Four Natural 1,7-Diarylheptanoids

Diarylheptanoids constitute a distinct group of metabolites of natural plant characterized by two aromatic rings linked by a linear seven aliphatic chain.There have been few reports on the biological activities of diarylheptanoids, most of which appearing in the areas of anti-inflammatory, anti-oxidative, superoxide scavenging and anti-hepatotoxic effects.Some of them are used as traditional medicine in Asia.Compounds 1 and 2 were firstly isolated from the rhizomes of Zingiber offical respectively.1-(3′,4′-Dihydroxyphenyl)-7-(4″-hydroxyphenyl)-4-hepten-3-one(4) was firstly isolated from the flowers of A.japonica.Herein, we report the synthesis of these four natural1,7-diarylheptanoids, 5-hydroxy-1-(4′-hydroxy-3′-methoxyphenyl)-7-(4″-hydroxyphenyl)-3-heptanone (1), 1-(4′-hydroxy-3′-methoxyphenyl)-7-(4″-hydroxyphenyl)hept-4-en-3-one (2)(Gingerenone C), 5-hydroxy-1-(3′,4′-dihydroxyphenyl)-7-(4″-hydroxyphenyl)-3-heptanone (3) and 1-(3′,4′-dihydroxyphenyl)-7-(4″-hydroxyphenyl)hept-4-en-3-one (4).And compounds 1, 2 and 4 were firstly synthesized.