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Increasing the antibacterial activity of gallium(III) against Pseudomonas aeruginosa upon coordination to pyridine-derived thiosemicarbazones |
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| Authors: | Jeferson G da Silva Lucas S Azzolini Solange MSV Wardell James L Wardell Heloisa Beraldo |
| Institution: | 1. Departamento de Química, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil;2. Departamento de Síntese Orgânica, Farmanguinhos – Fiocruz, Instituto de Tecnologia em Fármacos, Far-Manguinhos, FIOCRUZ, CEP 21041-250 Rio de Janeiro, RJ, Brazil |
| Abstract: | Reaction of N(4)-phenyl-2-formylpyridine thiosemicarbazone (H2Fo4Ph), N(4)-phenyl-2-acetylpyridine thiosemicarbazone (H2Ac4Ph) and N(4)-phenyl-2-benzoylpyridine thiosemicarbazone (H2Bz4Ph) with gallium nitrate gave Ga(H2Fo4Ph)2](NO3)3 (1), Ga(2Ac4Ph)2]NO3 (2) and Ga(2Bz4Ph)2]NO3 (3). In all complexes coordination of the thiosemicarbazone via the Npy–N–S chelating system occurs. In 1 the thiosemicarbazone acts as a neutral ligand while in 2 and 3 the ligand is anionic. Upon slow diffusion of 2 in DMSO Ga(2Ac4Ph)2]NO3·DMSO (2a) was formed. The crystal structure of 2a was determined. Upon coordination the antibacterial activity of both gallium and thiosemicarbazones against Pseudomonas aeruginosa significantly increases. |
| Keywords: | Thiosemicarbazones Gallium(III) complexes Antibacterial Pseudomonas aeruginosa |
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