Study on Infrared Transmission Spectrum of Sildenafil Citrate Mixed in Traditional Chinese Medicine |
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| Authors: | Yiling Wang Guiliang Chen Ziqiang Zhu Jianzhong Zhu and Wei Lu |
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| Institution: | (1) Shanghai Institute of Drug Control, Shanghai, 200233, China;(2) National Lab for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai, 200083, China;(3) Department of Electronic Engineering, East China Normal University, Shanghai, 200062, China |
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| Abstract: | The infrared transmission spectrum has been studied on the mixed medicine sample composed of sildenafil citrate (SDF or Viagra) and traditional Chinese medicine(TCM). The measured infrared spectra are composed of several broad absorption bands and many sharp absorption lines. Then the broad absorption bands are changed from sample to sample. It is identified that the sharp and broad absorption bands are from the Viagra and TCM, respectively. A numerical best fitting process has been used to extract the absorption spectrum from the spectrum of mixed sample. Combined with the numerical analysis, the Viagra component can be extracted from the mixed material even with a changeable broad absorption bands' background. It shows that the infrared transmission spectroscopy is a useful method to extract the component of chemical medicine from the mixed medicine. |
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| Keywords: | Sildenafil citrate Infrared Spectroscopy Traditional Chinese medicine Numerical analysis |
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