Crosslinked Networks Based on Polysaccharides and Collagen for Pilocarpine Sustained Release |
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| Authors: | Petruta Flocea Liliana Verestiuc Marcel Popa Valeriu Sunel Adriana Lungu |
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| Institution: | 1. “Gh. Asachi” Technical University, Faculty of Chemical Engineering and Environmental Protection, Department of Macromolecules , Iasi, Romania;2. Faculty of Medical Bioengineering , University of Medicine and Pharmacy , Iasi, Romania;3. University “Al. I.Cuza”, Department of Chemistry , Iasi, Romania;4. Polytechnic University, Faculty of Applied Chemistry and Materials Science , Bucharest, Romania |
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| Abstract: | The paper presents the experimental studies regarding synthesis and characterization of hydrogels based on gellan (Gel)/chitosan (CS) and collagen (Col), obtained by crosslinking with glutaraldehyde (GLA). The influence of the polysaccharide content and GLA ratio on the final composition and swelling characteristics was evaluated. Hydrogels swelling analysis, in distilled water and phosphate buffer (PBS, pH 7.2) has shown higher swelling degrees at increased concentration of polysaccharide into hydrogels. In vitro release of pilocarpine has demonstrated the possibility to use gellan-collagen and chitosan-collagen hydrogels as ophthalmic drug delivery matrix. |
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| Keywords: | Gellan chitosan collagen hydrogels ophthalmic drug delivery |
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