Poly(vinyl alcohol)-based Amphiphilic Copolymer Aggregates as Drug Carrying Nanoparticles |
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| Authors: | Miklós Nagy László Szöllösi Sándor Kéki Rudolf Faust Miklós Zsuga |
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| Institution: | 1. Department of Applied Chemistry , University of Debrecen , H-4010, Debrecen, Hungary;2. Department of Chemistry , University of Massachusetts Lowell, One, University Avenue , Lowell, MA, 01854 |
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| Abstract: | A series of amphiphilic polyisobutylene-block-poly(vinyl alcohol) (PIB-b-PVA) copolymers of constant PIB and varying PVA block length was synthesized by living carbocationic polymerization and their solution behavior was studied. The synthesis involved the preparation of polyisobutylene-b-poly(tert.-butyl vinyl ether) followed by hydrolysis with hydrogen bromide. The copolymers were characterized by gel permeation chromatography, 1H-NMR, and MALDI-TOF MS methods. The micellization behavior of the copolymers was investigated in aqueous media by direct dissolution and dialysis using static and dynamic light scattering. The critical micelle concentration, micelle size, aggregation number, and micelle shape were determined. The ability of the aggregates as drug carrying nanodevices was also investigated by doping them with indomethacin. UV-Vis measurements showed that the solubility of indomethacine increased significantly. Our findings suggest that the solubility is largely dependent upon the block segment ratios. |
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| Keywords: | Polyisobutylene poly(vinyl alcohol) block copolymer self assembly indomethacin |
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