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Biotinylated chitosan-based SPIONs with potential in blood-contacting applications |
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| Authors: | Vera Balan Ivona Andreea Petrache Marcel Ionel Popa Maria Butnaru Eugen Barbu John Tsibouklis Liliana Verestiuc |
| Affiliation: | (1) Faculty of Chemical Engineering and Environmental Protection, Technical University ‘Gh.Asachi’, 73 Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania;(2) Department of Biomedical Sciences, Faculty of Medical Bioengineering, ‘Gr.T.Popa’ University of Medicine and Pharmacy, 9-13 Kogalniceanu Street, 700454 Iasi, Romania;(3) School of Pharmacy and Biomedical Sciences, University of Portsmouth, St. Michael’s Building, White Swan Road, Portsmouth, PO1 2DT, UK; |
| Abstract: | Haemocompatible biotinylated superparamagnetic nanoparticles (size range 300–700 nm) have been obtained by coating magnetite through ionic gelation with a mixture of chitosan and sodium tripolyphosphate, followed by subsequent functionalisation with biotin. The evaluations of their magnetic properties together with haemocompatibility tests have shown that these nanoparticles exhibit the prerequisite behaviour for use in magnetic field–assisted separations within biological systems. |
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