Multicatalytic synthesis of 1,2-dihydroisoquinolin-1-ylphosphonates via a tandem four-component reaction |
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| Authors: | Haibo Zhou Shengqing Ye Jie Wu |
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| Affiliation: | a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China |
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| Abstract: | A tandem four-component reaction of 2-bromobenzaldehyde, alkyne, amine, and diethyl phosphite catalyzed by the combination of palladium and copper salts provides a facile and efficient route to 1,2-dihydroisoquinolin-1-ylphosphonate. A cascade Sonogashira-intramolecular cyclization-nucleophilic addition may be involved in the reaction process. |
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| Keywords: | 2-Bromobenzaldehyde Diethyl phosphite 1,2-Dihydroiso-quinolin-1-ylphosphonate Four-component reaction Multicatalysis |
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