Thermal degradation behavior of some ruthenium complexes with fluoroquinolone derivatives as potential antitumor agents |
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| Authors: | Valentina Uivarosi Mihaela Badea Rodica Olar Dana Marinescu Teodor Octavian Nicolescu George Mihai Nitulescu |
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| Affiliation: | (1) Department of Inorganic Chemistry, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str, Bucharest, Romania;(2) Faculty of Chemistry, Department of Inorganic Chemistry, University of Bucharest, 90-92 Panduri St., 050663 Sector 5, Bucharest, Romania;(3) Department of Organic Chemistry, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str, Bucharest, Romania;(4) Department of Pharmaceutical Chemistry, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str, Bucharest, Romania; |
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| Abstract: | Three new complexes with ligands belong to the fluoroquinolone class having the general formula [RuL2Cl2]Cl nH2O ((1) L: norfloxacin (nf), n = 4; (2) L: ciprofloxacin (cp), n = 3; (3) L: enrofloxacin (enro), n = 5) were synthesized and characterized by chemical analysis UV–Vis and IR spectroscopy. In all complexes fluoroquinolone derivative acts as bidentate chelate ligand. The thermal behavior steps were investigated in synthetic air flow. The thermal transformations are complex processes according to TG and DTG curves including dehydration, quinolone derivative degradation, as well as RuCl3 conversion in RuO2. |
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