Highly Enantioselective Iridium‐Catalyzed Hydrogenation of α,β‐Unsaturated Esters |
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| Authors: | Jia‐Qi Li Xu Quan Prof. Dr. Pher G. Andersson |
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| Affiliation: | 1. Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, 75123, Uppsala (Sweden), Fax: (+46)?18‐471‐3818;2. School of Chemistry, University Of KwaZulu‐Natal, Durban (South Africa) |
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| Abstract: | α,β‐Unsaturated esters have been employed as substrates in iridium‐catalyzed asymmetric hydrogenation. Full conversions and good to excellent enantioselectivities (up to 99 % ee) were obtained for a broad range of substrates with both aromatic‐ and aliphatic substituents on the prochiral carbon. The hydrogenated products are highly useful as building blocks in the synthesis of a variety of natural products and pharmaceuticals. |
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| Keywords: | asymmetric catalysis chirality hydrogenation iridium α ,β ‐unsaturated esters |
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