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Enantioseparation of α‐hydroxy acids by chiral ligand exchange CE with a dual central metal ion system |
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| Authors: | Shuji Kodama Atsushi Yamamoto Sen‐ichi Aizawa Yoshitaka Honda Kentaro Suzuki Tomoko Kemmei Atsushi Taga |
| Institution: | 1. Toyama Institute of Health, , Imizu, Toyama, Japan;2. Department of Biological Chemistry, College of Bioscience and Biotechnology, Chubu University, , Kasugai‐shi, Aichi, Japan;3. Graduate School of Science and Engineering, University of Toyama, , Toyama, Japan;4. Fukushima Factory, GL Sciences Inc., , Okajima, Fukushima, Japan;5. Faculty of Pharmacy, Kinki University, , Higashi‐Osaka, Japan |
| Abstract: | Using two kinds of central metal ions in a background electrolyte, ligand exchange CE was investigated for the simultaneous enantioseparation of dl ‐malic, dl ‐tartaric, and dl ‐isocitric acids. Ligand exchange CE with 100 mM d ‐quinic acid as a chiral selector ligand and 10 mM Cu(II) ion as a central metal ion could enantioseparate dl ‐tartaric acid but not dl ‐malic acid or dl ‐isocitric acid. A dual central metal ion system containing 0.5 mM Al(III) ion in addition to 10 mM Cu(II) ion in the background electrolyte enabled the simultaneous enantioseparation of the three α‐hydroxy acids. These results suggest that the use of a dual central metal ion system can be useful for enantioseparation by ligand exchange CE. |
| Keywords: | α ‐Hydroxy acid Capillary electrophoresis Dual central metal ion Enantioseparation Ligand exchange |