Two New Triterpene Saponins from Cyclamen africanum Boiss. & Reuter |
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| Authors: | Soumeya Bencharif‐Betina Tomofumi Miyamoto Chiaki Tanaka Zahia Kabouche Anne‐Claire Mitaine‐Offer Marie Aleth Lacaille‐Dubois |
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| Institution: | 1. EA 4267, FDE/UFC, Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, 7, Bd Jeanne d'Arc, BP 87900, F‐21079 Dijon Cedex, (phone: +33‐3‐80393229;2. fax: +33‐3‐80393300);3. Laboratoire d'Obtention des Substances Thérapeutiques, L.O.S.T., Faculté des Sciences, Université de Constantine, Algérie;4. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan |
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| Abstract: | Two new oleanane‐type triterpene saponins, afrocyclamins A and B ( 1 and 2 , resp.), were isolated from a MeOH extract of the roots of Cyclamen africanum Boiss . & Reuter , together with three known triterpenoid saponins, lysikokianoside, deglucocyclamin I, and its dicrotalic acid derivative. The structures were elucidated, on the basis of 1D‐ and 2D‐NMR experiments and mass spectrometry as (3β,20β)‐13,28‐epoxy‐16‐oxo‐3‐{O‐β‐D ‐xylopyranosyl‐(1→2)‐O‐β‐D ‐glucopyranosyl‐(1→4)‐O‐β‐D ‐glucopyranosyl‐(1→2)]‐α‐L ‐arabinopyranosyl}oxy}oleanan‐29‐al ( 1 ) and (3β,16α,20β)‐16,28,29‐trihydroxy‐olean‐12‐en‐3‐yl O‐4‐O‐(4‐carboxy‐3‐hydroxy‐3‐methyl‐1‐oxobutyl)‐β‐D ‐xylopyranosyl‐(1→2)‐O‐β‐D ‐glucopyranosyl‐(1→4)‐O‐β‐D ‐glucopyranosyl‐(1→2)]‐α‐L ‐arabinopyranoside ( 2 ). |
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| Keywords: | Cyclamen africanum Triterpenes Afrocyclamins A and B Saponins |
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