2‐Amino‐1,2,3,6‐tetrahydro‐6‐oxocyclopenta[c]fluorene‐2‐carboxylic Acid (FlAib), a Completely Rigidified,Fluoren‐9‐one‐Based α‐Amino Acid |
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| Authors: | Karen Wright Antonio Blanco Alvarez Marco Crisma Antonio Toffoletti Fernando Formaggio Claudio Toniolo |
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| Affiliation: | 1. ILV UMR 8180, University of Versailles, FR‐78035 Versailles);2. Institute of Biomolecular Chemistry, Padova Unit, CNR, Department of Chemistry, University of Padova, IT‐35131 Padova |
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| Abstract: | ![]()
The synthesis, optical resolution, determination of absolute configuration and conformational preference, and spectroscopic characteristics of terminally protected (blocked) derivatives and short peptides of 2‐amino‐1,2,3,6‐tetrahydro‐6‐oxocyclopenta[c]fluorene‐2‐carboxylic acid (FlAib), a novel, rigid, chiral, cyclized Cα,α‐disubstituted glycine are described. |
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| Keywords: | Amino acids Glycine Peptides X‐Ray crystallography |
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