A New Alkaloid from the Seeds of Sophora alopecuroides L. |
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| Authors: | Hong‐Ying Gao Guo‐Yu Li Jin‐Hui Wang |
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| Institution: | 1. School of Pharmacy, Shihezi University, Shihezi 832002, P.?R. China, (phone/fax: +86‐993‐2055001);2. School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, P.?R. China (phone/fax: +86‐24‐23986479);3. Key Laboratory of Phytomedicine Resources & Modernization of TCM, Shihezi 832002, P.?R. China |
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| Abstract: | Alopecurin A, an alkaloid with an unprecedented skeleton, was isolated from the seeds of Sophora alopecuroides L. The absolute configuration and structure of this compound was identified as (3S,12R)‐3‐hydroxy‐1,7‐diazatricyclo10.4.0.13,7]heptadecane‐11,16,17‐trione (=(7S,15aR)‐decahydro‐7‐hydroxy‐6H‐7,11‐methano‐4H‐pyrido1,2‐a]1,7]diazacyclododecine‐4,15,16(12H)‐trione). The structure and absolute configuration was elucidated by spectroscopic methods, mainly HR‐ESI‐TOF‐MS, IR, 1D‐NMR (1H‐ and 13C‐NMR), 2D‐NMR (COSY, NOESY, HSQC, HMBC), and particularly X‐ray crystal‐diffraction and CD spectral analysis. |
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| Keywords: | Sophora alopecuroides Alkaloids Alopecurin A X‐Ray crystallography |
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