1,4‐Dipolar Cycloaddition Reactions in Ionic Liquids: A Facile Synthesis of 9aH,15H‐[1]Benzopyrano[3′,2′: 3,4]pyrido[2,1‐a]isoquinolines (=9aH,15H‐Benzo[a][1]benzopyrano[2,3‐h]quinolizines) |
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| Authors: | Basi V Subba Reddy Nagendra Nath Yadav Nikhil Srivastava Jhillu S Yadav Balasubramanian Sridhar |
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| Institution: | 1. Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad‐500 007, India, (fax: +91‐40‐27160512);2. Centre for X‐Ray Crystallography, Indian Institute of Chemical Technology, Hyderabad‐500 007, India |
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| Abstract: | Ionic liquids were found to be a suitable reaction medium for 1,4‐dipolar cycloaddition reactions of an isoquinoline, an activated alkyne, and a 4‐oxo‐4H‐1‐benzopyran‐3‐carboxaldehyde at room temperature to afford 1]benzopyrano‐pyrido‐isoquinoline (=9aH,15H‐benzoa]1]benzopyrano2,3‐h]quinolizine) derivatives selectively in good yields. The ionic liquid can be recovered and recycled in further runs without loss of activity. |
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| Keywords: | [1]Benzopyranopyrido‐isoquinolines Benzo‐[1]benzopyrano‐quinolizines Cycloadditions X‐Ray crystallography Ionic liquids Multicomponent reactions |
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