A Total Synthesis of Aliskiren |
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| Authors: | Gyeok Nam Soo Y Ko |
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| Institution: | 1. Department of Chemistry, Ewha Womans University, Seoul 120‐750, Korea, (phone: +822‐3277‐3283;2. fax: +822‐3277‐2384) |
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| Abstract: | A total synthesis of aliskiren ( 20 ) was accomplished. A key in our synthesis was to use the symmetric trans‐cisoid‐trans‐bis‐lactone 1 as a precursor. It was expediently prepared by three different routes (Scheme 2). Appending the end groups and functional group transformations completed the synthesis (Scheme 3). |
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| Keywords: | Aliskiren |
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