An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica |
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| Authors: | Boris Pejin Ana Ciric Mladen Horvatovic Tamara Jurca Jasmina Glamoclija Milos Nikolic |
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| Institution: | 1. Department of Life Sciences, Institute for Multidisciplinary Research – IMSI, University of Belgrade, Belgrade, Serbiaborispejin@imsi.rs;3. Mycological Laboratory, Department of Plant Physiology, Institute for Biological Research “Sinisa Stankovic”, University of Belgrade, Belgrade, Serbia;4. Faculty of Sciences, Department of Biology and Ecology, University of Novi Sad, Novi Sad, Serbia |
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| Abstract: | The antimicrobial activity of five crude extracts of the freshwater bryozoan Pectinatella magnifica (Leidy, 1851) was evaluated in vitro for the first time. P. magnifica acetone extract exhibited the highest antibacterial activity (minimum inhibitory concentrations (MIC) 0.004–0.350 mg/mL and MBC 0.007–0.500 mg/mL), while its methanol extract showed the most promising antifungal activity (MIC 0.03–0.12 mg/mL and MFC 0.06–0.25 mg/mL). Furthermore, at a concentration of 0.25 MIC, the methanol extract reduced biofilm formation of the bacterial strain Pseudomonas aeruginosa PAO1 in a considerable extent (59.14%). FTIR spectra of the most active extracts indicate the presence of carbonyl compounds, long-chain alcohols and/or sterols. According to the experimental data obtained, P. magnifica methanol extract may be considered as a good resource of novel natural products with potent antibiofilm activity against the bacterium well known for its resistance. |
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| Keywords: | Bryozoa extracts antibiofilm activity Pseudomonas aeruginosa PAO1 |
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