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Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria |
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| Authors: | Pakorn Wattana-Amorn Waranya Charoenwongsa Christopher Williams Matthew P. Crump |
| Affiliation: | 1. Faculty of Science, Department of Chemistry, Center of Excellence for Innovation in Chemistry and Special Research Unit for Advanced Magnetic Resonance, Kasetsart University, Bangkok, Thailandfscipwa@ku.ac.th;3. Faculty of Science, Department of Chemistry, Center of Excellence for Innovation in Chemistry and Special Research Unit for Advanced Magnetic Resonance, Kasetsart University, Bangkok, Thailand;4. School of Chemistry, University of Bristol, Bristol, United Kingdom |
| Abstract: | Two bioactive cyclic dipeptides, cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr), were isolated from the culture broth of Streptomyces sp. strain 22-4 and tested against three economically important plant pathogens, Xanthomonas axonopodis pv. citri, Ralstonia solanacearum and Clavibacter michiganensis. Both cyclic dipeptides were active against X. axonopodis pv. citri and R. Solanacearum with MIC of 31.25 μg/mL. No activity could be observed against C. michiganensis. |
| Keywords: | Cyclo( smallcaps smallerCapital" >L-Pro- smallcaps smallerCapital" >L-Tyr) cyclo( smallcaps smallerCapital" >D-Pro- smallcaps smallerCapital" >L-Tyr) Streptomyces phytopathogenic bacteria |