Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats |
| |
| Authors: | M Cristani F Mancari T Arcoraci D Ferrari D Fratantonio |
| |
| Institution: | Department of Drug Sciences and Health Products, University of Messina, Messina, Italy |
| |
| Abstract: | Acetaminophen (N-acetyl-p-aminophenol, APAP) overdosage can produce fatal centrilobular hepatic necrosis in humans. The present study attempted to investigate the protective effect of an anthocyanin-rich extract from bilberries and blackcurrants (AE) against APAP-induced acute hepatic damage in rats. Treatment with AE normalised blood activities of glutamate oxaloacetate and glutamate pyruvate transaminase and prevented APAP-induced plasmatic and tissutal alterations in biomarkers of oxidative stress, probably due to various bioproperties of the components of the extract. |
| |
| Keywords: | Acetaminophen hepatoprotection anthocyanin oxidative stress biomarkers |
|
