Anti-phytopathogen,multi-target acetylcholinesterase inhibitory and antioxidant activities of metabolites from endophytic Chaetomium globosum |
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| Authors: | Wei Li Xueqiong Yang Yabin Yang Rongting Duang Guangyi Chen Xiaozhan Li |
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| Institution: | 1. School of Chemical Science and Technology, Yunnan University, Kunming, People’s Republic of China;2. School of Pharmaceutical Sciences, Kunming Medical University, Kunming, People’s Republic of China |
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| Abstract: | Fourteen metabolites with various structure types were isolated from endophytic Chaetomium globosum. Five compounds were separated from genus Chaetomium for the first time. Some compounds exhibited remarkable inhibition against phytopathogenic fungi causing root rot of Panax notoginseng. Compounds 1–5 had significant DPPH-free radical-scavenging activity. Compounds 3 and 5 indicated significant inhibitions against the acetylcholinesterase (AChE). From preliminary structure–activity relationship, it was found that the oxygenic five-membered ring of 3 and 5 was crucial in the anti-AChE activity. These structures provide new templates for the potential treatment and management of plant diseases and Alzheimer disease. |
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| Keywords: | Chaetomium globosum metabolite anti-phytopathogen anti-AChE antioxidant |
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