Chemoselective synthesis and spectral studies of N-thiocyanatoacetyl derivatives of 3-alkyl-2,6-diarylpiperidin-4-ones |
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| Authors: | M. Velayutham Pillai K. Rajeswari C. Udhaya Kumar C. Ramalingan A. Manohar |
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| Affiliation: | 1. Department of Chemistry, Annamalai University, Annamalai Nagar, Tamil Nadu, India;2. Department of Chemistry, Kalasalingam University, Krishnan Kovil, Tamil Nadu, India;3. Department of Chemistry, Kalasalingam University, Krishnan Kovil, Tamil Nadu, India |
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| Abstract: | A series of N–thiocyanatoacetyl derivatives of 3–alkyl–2,6–diarylpiperidin–4–ones has been synthesized by the reaction between the N–chloroacetyl derivatives of the respective piperidin–4–ones and the ambident thiocyanate nucleophile. The synthesized compounds have been characterized through FT–IR, 1H, 13C, 1H–1H COSY, 1H–13C COSY and NOESY spectra. The spectral data reveal the conformational priority of the six-membered heterocyclic ring. |
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| Keywords: | Chemoselective piperidin-4-ones thiocyanatoacetyl NMR spectra stereochemistry |
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