A new sesquiterpenoid quinone with cytotoxicity from Abelmoschus sagittifolius |
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| Authors: | De-Li Chen Xiao-Po Zhang Guo-Xu Ma Hai-Feng Wu Jun-Shan Yang |
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| Institution: | 1. Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences &2. Peking Union Medical College, Wanning 571533, P.R. China;3. School of Pharmaceutical Science, Hainan Medical University, No.3 Xueyuan Road, Longhua District, Haikou 571101, P.R. China;4. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences &5. Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, P.R. China |
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| Abstract: | A new sesquiterpenoid quinone, Acyl hibiscone B (1), together with five known compounds, (R)-lasiodiplodin (2), (R)-de-O-methyllasiodiplodin, (3) dibutyl phthalate (4), (R)-9-phenylnonan-2-ol (5) and hibiscone B (6), was obtained from the stem tuber of Abelmoschus sagittifolius. The structure of compound 1 was elucidated by analysing its 1H and 13C NMR, 1H–1H COSY, HSQC, HMBC, NOESY and HR-ESI-MS values. Compound 1 showed significant cytotoxicity against Hela and HepG-2 human cancer cell lines. |
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| Keywords: | Abelmoschus sagittifolius sesquiterpenoid cytotoxicity |
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