New α-glucosidase inhibiting anthracenone from the barks of Harungana madagascariensis Lam |
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| Authors: | Ismail B Onajobi Shabbir Hussain Kulsoom Javaid Obasola E Fagade I A Oladosu |
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| Institution: | 1. Department of Microbiology, Olabisi Onabanjo University, Ago-Iwoye, Nigeria;2. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;3. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;4. Environmental and Biotechnology Unit, Department of Microbiology, University of Ibadan, Ibadan, Nigeria;5. Department of Chemistry, University of Ibadan, Ibadan, Nigeria |
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| Abstract: | Two new 10-hydroxy-9(10H)-anthracenone, madagascenone A (1) and B (2), were isolated from the barks of Harungana madagascariensis Lam. The structures of the compounds were determined using 1D- and 2D-NMR and mass spectroscopic techniques. Both of the compounds showed an in vitro α-glucosidase inhibition with IC50 = 69.9 ± 4.21 and 122.3 ± 1.13 μM, respectively, more potent than the standard acarbose (IC50 = 840 ± 1.23 μM). |
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| Keywords: | Harungana madagascariensis madagascenone A and B α-glucosidase inhibition |
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