A new anthraquinone from seed of Cassia obtusifolia |
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Authors: | Bao-jun Shi Wei-dong Zhang Hong-fang Jiang Yu-yao Zhu Lei Chen Xiao-ming Zha |
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Institution: | 1. Nanjing Institute for Comprehensive Utilization of Wild Plants, Nanjing 210042, P.R. China;2. Department of Pharmacy, School of Stomatology, Fourth Military Medical University, Xi'an 710032, P.R. China;3. College of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, P.R. China |
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Abstract: | Seeds of Cassia obtusifolia L. are known as homology of medicine and food material, which is a commonly consumed beverage in China. One new compound, 8-hydroxy-1,7-dimethoxy-3-methylanthracene-9,10-dione-2-O-β-d-glucoside (1), together with 11 known compounds, including seven anthraquinones (2–8), was isolated from the seeds. The 2D NMR data of compound 2 are reported for the first time. The structures of the compounds were established on the basis of 1D and 2D NMR, IR and HR-ESI-MS spectra. The cytotoxic activities of all the compounds against five cell lines (LO2, HCT-116, A549, HepG2 and SGC7901) were evaluated by using CCK8 methods. Compounds 1, 3 and 7 show moderate cytotoxicity towards HCT-116 cells compared with oxaliplatin. |
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Keywords: | Cassia obtusifolia anthraquinone antineoplastic activity |
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