Three new 2,5-diketopiperazines from the fish intestinal Streptomyces sp. MNU FJ-36 |
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| Authors: | Yi-xin Ou Jia-fu Huang Xiu-min Li |
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| Affiliation: | 1. Engineering Technological Center of Mushroom Industry, Minnan Normal University, Zhangzhou, P.R. China;2. College of Life Sciences and Technology, Minnan Normal University, Zhangzhou, P.R. China |
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| Abstract: | The gut actinobacteria of marine-inhabited fish is one of the most important reservoirs of novel natural products. Currently, the Streptomyces sp. MNU FJ-36 was isolated from the intestinal fabric of Katsuwonus sp. and determined by 16S rRNA analysis. From the cultures of the S. sp. MNU FJ-36, three new 2,5-diketopiperazines (2,5-DKPs) were discovered and identified as 3-(3-hydroxy-4-methoxybenzyl)-6-isobutyl-2,5-diketopiperazine (1), 3-(1,3-benzodioxol-5-ylmethyl)-6-isobutyl-2,5-diketopiperazine (2) and 3-(1,3-benzodioxol-5-ylmethyl)-6-isopropyl-2,5-diketopiperazine (3). Their structures were elucidated on the basis of spectroscopic data analysis. All the compounds were also evaluated for their inhibitory activity against P388, A-549 and HCT-116 cell lines with the MTT assay. |
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| Keywords: | Intestinal Streptomyces diketopiperazine cyclodipeptide cytotoxicity |
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