Officinalioside,a new lignan glucoside from Borago officinalis L. |
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| Authors: | Mamdouh Nabil Samy Ashraf Nageeb El-Sayed Hamed Sachiko Sugimoto Hideaki Otsuka Mohamed Salah Kamel |
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| Institution: | 1. Department of Pharmacognosy, Graduate School of Biomedical &2. Health Sciences, Hiroshima University, Hiroshima, Japan;3. Faculty of Pharmacy, Department of Pharmacognosy, Minia University, Minia, Egypt;4. Faculty of Pharmacy, Department of Pharmacognosy, Minia University, Minia, Egypt;5. Faculty of Pharmacy, Department of Natural Product Chemistry, Yasuda Women’s University, Hiroshima, Japan |
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| Abstract: | A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O-β-D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses. Compounds 1 and 2 showed a moderate DPPH radical scavenging activity (IC50: 52.6 ± 1.70 and 41.3 ± 0.25 μM, respectively) comparable with that of the standard trolox (16.6 ± 2.2 μM) without any significant cytotoxicity towards human cell line A549 (IC50 > 100 μM). |
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| Keywords: | Borago officinalis Boraginaceae lignan officinalioside DPPH cytotoxicity |
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