A new cytotoxic biflavonoid from the rhizome of Wikstroemia indica |
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| Authors: | Meng Shao Xiao-Jun Huang Jun-Shan Liu Wei-Li Han Hong-Bing Cai |
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| Affiliation: | 1. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China;2. Institute of Traditional Chinese Medicine &3. Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China;4. Hygiene Detection Center, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China |
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| Abstract: | ![]()
One new chalcone-flavone biflavonoid, 3′-hydroxydaphnodorin A (1), together with 12 known biflavonoids (2–13), was isolated from the rhizome of Wikstroemia indica. Their structures were established on the basis of extensive spectroscopic methods. Eight isolated compounds 1–3, 6, 7, 9, 12 and 13 were evaluated for their cytotoxic activities against cancer-derived cell lines Hep3B, HepG2 and CNE2, and 1 was found to possess moderate cytotoxicity against HepG2 and CNE2 cell lines, with IC50 values of 65.5 ± 11.4 and 53.6 ± 10.1 μM, respectively. |
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| Keywords: | Wikstroemia indica biflavonoid 3′-hydroxydaphnodorin A cytotoxicity |
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