A new coumarin from stem bark of Mesua hexapetala |
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| Authors: | Thiruventhan Karunakaran Soek Sin Teh Shaari Daud Siau Hui Mah Chan Kiang Lim |
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| Institution: | 1. Faculty of Science, Department of Chemistry, Universiti Putra Malaysia, Serdang, Malaysia;2. Faculty of Applied Science, Universiti Teknologi MARA, Jengka, Malaysia;3. School of Biosciences, Taylor’s University, Subang Jaya, Malaysia;4. Faculty of Science, Department of Chemical Sciences, Universiti Tunku Abdul Rahman, Kampar, Malaysia |
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| Abstract: | A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4), and four common triterpenoids, friedelin (5), stigmasterol (6), beta-sitosterol (7) and gamma-sitosterol (8) were isolated from the stem bark of Mesua hexapetala (Clusiaceae), a plant, native to Malaysia. The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. Anti-inflammatory activity assay indicated hexapetarin (1) to possess moderate anti-inflammatory activity, while 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4) gave very good activity. |
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| Keywords: | Mesua hexapetala coumarin xanthone anti-inflammatory |
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