Cationic gemini guests promote the efficient self-assembly of capsular entities in water at neutral pH |
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Authors: | Carmelo Sgarlata Giuseppe Arena Cosimo G Fortuna Domenico Sciotto |
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Institution: | Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Catania, Italy |
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Abstract: | AbstractThe binding features of a sulfonato-calix4]arene with pyridinium-based gemini guests have been investigated in water at physiological condition by NMR spectroscopy. Results provided converging evidence showing that guests having different size, shape and flexibility formed water-soluble homodimeric supramolecular capsules. The remarkably large encapsulation efficiency of the anionic calixarene host towards these bis(pyridinium) gemini guests results from the favourable combination of electrostatic and hydrophobic interactions. The introduction of short and rigid spacers between the two positively charged heads of the guest improves the efficiency of the capsule formation. The insertion of a substituent into the pyridinium ring of the guest dramatically affects both the association constants and the binding modes. |
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Keywords: | sulfonato-calixarene gemini guest water-soluble capsules self-assembly |
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