New jacaranone glucoside from Jacaranda oxyphylla leaves |
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| Authors: | V V Pereira L P Duarte R R Silva J A Takahashi |
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| Institution: | 1. Chemistry Department, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;2. Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazilvncsviana@ufmg.br;4. Chemistry Department, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brazil |
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| Abstract: | Jacaranda oxyphylla Cham. is popularly known as ‘caroba-de-São-Paulo’ and it is used in traditional medicine for microbial infections. A new phytoquinoid (α/β-glucoside-4-phenylacetate-6-(1-hydroxy-4-oxo-2,5-cyclohexadiene-1-acetate) (1) was isolated from J. oxyphylla leaves, together with three known compounds: quercetin-3-O-β-d-galactoside (2), verbascoside (3) and polystyrene (4). Their chemical structures were elucidated using spectroscopic techniques and by comparison with the related known compounds. In addition, it was found a pronounced acetylcholinesterase inhibitory activity for the quinoid 1 (100.0 ± 0.8%) and phenolic compounds 2 and 3 (99.9 ± 0.7 and 99.3 ± 0.5%, respectively), if compared to the standard eserine (92.7 ± 0.4%), that was analysed by a microplate spectrophotometer. |
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| Keywords: | Bignoniaceae Jacaranda oxyphylla quinoid antiacetylcholinesterase activity |
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